What does HO-1 stand for?

J. Gastroenterol. Hepatol. 23, S229–S233 (2008). Paul, G. et al. Analysis of intestinal haem-oxygenase-1 (HO-1) in clinical and experimental colitis. Clin. Exp. Immunol. 140, 547–555 (2005). Fagone, P. et al. Heme oxygenase-1 expression in peripheral blood mononuclear cells correlates with disease activity in multiple sclerosis. J.

Where is HO-1 found?

The full-length and truncated form of HO-1 (t-HO-1) are found in the nucleus, in which it regulates gene expressions involved in angiogenesis, anti-apoptotic proteins, anti-oxidative enzymes, metastasis, and mitochondrial biogenesis. The 14 kDa HO-1 variant is retained in the cytosol. 4.2. HO-1 in Mitochondria

Why is HO-1 important?

Renal tubuli are constantly exposed to oxidative agents and stress conditions potentially resulting in damage of the entire renal system, in this context HO-1 has a key role protecting these important structures and its deficiency leads to higher susceptibility to tubular epithelial injury, as shown in various animal models [ 114, 116, 117 ].